Thinking of starting your **Synedica Retatrutide pen**? Here’s your clean, no-fluff walkthrough on how to safely inject, store, and dose it — all based on the official instructions.
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- - - Synedica Retatrutide 40mg multi-dose pen
- - 12 disposable needles (up to 8mm)
- - Instruction sheet inside box lid
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- - - **Before first use:**
Store in the **fridge (2–8°C)**, never freeze, keep out of sunlight.
- - **After first use:**
- - - Store up to **16 weeks in the fridge**, or
- - **6 weeks below 30°C** (room temp)
- - Always keep the **pen capped**
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| Weeks | Dose (Once Weekly) |
|-------|---------------------|
| 1–4 | 2.5 mg |
| 5–8 | 5 mg |
| 9–12 | 7.5 mg |
| 13+ | 10 mg (if advised) |
Stick to the same **day of the week** for injections.
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- - 1. Wash your hands
- 2. Check the pen label + solution (clear, not cloudy)
- 3. Attach a new needle
- - - Remove seal
- - Screw on needle
- - Remove outer and inner caps
- 4. Turn dose dial to **2.5, 5, 7.5 or 10 mg**
- - - Align number with dose window
- 5. Pick injection site: thigh, abdomen, or arm
- - - Rotate sites weekly
- 6. Clean skin with alcohol swab
- 7. Inject under the skin
- - - Pinch, insert, press button, hold
- 8. Remove needle carefully
- - - Cap, unscrew, and dispose in sharps bin
- 9. Replace pen cap
- 10. Log your dose + rotate site
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- - - If **< 5 days late**: Take it, then resume normal schedule
- - If **> 5 days late**: Skip dose, wait for next regular day
- - **Do not double up**
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- - - **Common**: nausea, vomiting, diarrhea, constipation
- - **Rare but serious**:
- - - Stomach pain → pancreatitis
- - Allergy (swelling, breathing issues)
- - Hypoglycemia if taken with insulin or sulfonylureas
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- - - Inject at night to sleep through side effects
- - Use ginger tea or small meals if nauseous
- - Keep hydrated
- - Let the pen warm for 10–15 mins before use
- - Log injection sites and times
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Retatrutide activates **GLP-1, GIP, and glucagon receptors**, making it stronger than semaglutide or tirzepatide for fat loss.
Studies show up to **24.2% weight loss** over 48 weeks — it’s called the *“Godzilla” of GLP-1s* for a reason.
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